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Since the New York incident, Tony Stark (Robert Downey Jr., Jr.) has been troubled by unprecedented anxiety disorder. He is crazy about the research and development of the upgraded version of Iron Man, so he forgets to eat and sleep, and even ignores the feelings of his girlfriend, Pepper Potts (Gwyneth Paltrow). At the same time, the notorious terrorist leader Mandalin (Ben Kingsley) has created a series of explosive attacks. Tony's most loyal bodyguard was seriously injured in the latest attack. Not long after, Tony, Pepper and Maya (Rebecca Hall), the female botanist with whom he once met, were almost killed by fierce gunfire at home, which seems to be related to the research of Aldrich Killen (Guy Pearce), the scientist who met by chance 22 years ago, and his ultimate biology, I can't relieve my anxiety from the bottom of my heart. Tony, who was shattered, how to cross the raging fire from hell

Tony Stark, the Iron Man (Robert Downey Jr., Jr.) refuses to hand over the latest technology at the congressional hearing. At the same time, he found that the micro electric arc reactor in his chest was rapidly poisoning the blood with palladium. Depressed, Tony hands over the position of president of Stark Company to Secretary Boz (Gwyneth Paltrow), who takes full charge of the ongoing Stark Expo in New York. Boz transfers an assistant Natalie (Scarlett Johansson) from the legal department to take care of Tony. Tony's high-profile appearance in front of the media caused the dissatisfaction of Ivan (Mickey Locke, played by Mickey Rourke), the son of his father's former colleague. In order to retaliate, his son inherited his father's work and developed a set of equipment comparable to the steel battle suit. Ivan's technology has attracted the attention of Justin Hammer (Sam Rockwell), a competitor of Tony and an arms dealer. He tries to kidnap Ivan out of prison and secretly research to replace Iron Man. While Tony is suffering from the frustration caused by palladium metal poisoning, he finds that Natalie was originally on a secret mission, and his capriciousness has also caused a confrontation with his friend, Air Force Colonel Ronnie (Don Cheadle, Don Chandler), who sees the situation going out of control

In the winter of 1982, a helicopter of the Norwegian scientific research team suddenly broke the peace of the Antarctic continent, chasing a sled dog crazily, and finally crashed near the American scientific research camp. American scientific research team members have heard about the sudden decline of the Norwegian investigation team recently, so pilot Mike (Kurt Russell) and others rush to the Norwegian camp, only to see strange corpses scattered everywhere in the dilapidated land, and there is evidence that the Norwegian people have obtained some kind of creatures in the ice state. Doctor Blair (Wilford Brimley) studies the variation of the corpse, but is unable to decipher the cause. That night, the dog in the dog cage was attacked and mutated, and an unknown creature was threatening the lives of the scientific research team in the lonely Antarctic continent...
This film is a remake of The Thing From Another World directed by Howard Hawkes in 1951